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目錄編號：05111-60
描述
單克隆抗體的特異性反應的HIT3a的CD3 / T淋巴細胞抗原受體復合物的ε鏈。CD3復合物的TCR復雜的部分，由所有成熟T淋巴細胞和胸腺細胞系的表達。CD3增強的信號轉導的抗原識別。
與TCR復合物抗體HIT3a交叉鏈接，啟動細胞的活化和增殖，但它不能用于細胞CD3染色，由于它能夠染色只有表面CD3復合物。
Catalogue Number : 05111-60
Description
The Hit3a monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.
The HIT3a antibody cross-links with the TCR complex, initiating the cellular activation and proliferation, but it cannot be used for intracellular CD3 staining, as it is able to stain only the surface CD3 complex.
Additional Information
Clone
Hit3a
Format:
PE
Applications
FC
Reactivity
Human
Isotype:
Mouse IgG2a, kappa
Research Interest: Adaptive Immunity
Cell Type: NK and NKT Cells, T Cells, Treg cells, Th17 cells
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:
McMichael, A. J. (1987). Leucocyte typing III. Oxford University Press, Oxford. Norton AJ, Isaacson PG (1985)
Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York
Lanier, L. L., Allison, J. P., & Phillips, J. H. (1986). Correlation of cell surface antigen expression on human thymocytes by multi-color flow cytometric analysis: implications for differentiation. The Journal of Immunology, 137(8), 2501-2507.